Salbutamol

Side Effects

Immune system disorders – Very rare: Hypersensitivity reactions including angioedema, urticaria, bronchospasm, hypotension and collapse.Metabolism and nutrition disorders – Rare: Hypokalaemia. Potentially serious hypokalaemia may result from beta2 agonist therapy.Nervous system disorders – Very common: Tremor. Common: Headache. Very rare: Hyperactivity.Cardiac disorders – Common: Tachycardia, palpitations. Rare: Cardiac arrhythmias including atrial fibrillation, supraventricular tachycardia and extrasystoles.Vascular disorders- Rare: Peripheral vasodilatation.Musculoskeletal and connective tissue disorders – Common: Muscle cramps. Very rare: Feeling of muscle tension.

Drug Interactions

Propranolol , monoamine oxidase inhibitors (MAOIs) , digoxin , theophylline or aminophylline) , prednisolone , (such as frusemide) , such as insulin, metformin or glibenclamide .

Indication

Salbutamol are indicated for the relief of bronchospasm in bronchial asthma of all types, chronic bronchitis and emphysema.

When not to Use

It is contra-indicated in patients with a history of hypersensitivity to any of their components. Non-i.v. formulations of must not be used to arrest uncomplicated premature labour or threatened abortion.

Precaution

Potentially serious hypokalaemia may result from beta2 agonist Particular caution is advised in acute severe asthma as this effect may be potentiated by concomitant treatment with xanthine derivatives, steroids, diuretics and by hypoxia. It is recommended that serum potassium levels are monitored in such situations.therapy mainly from parenteral and nebulised administration.