Used For

Benign Prostatic Hyperplasia

Tamsulosin HCl inhibits a1a and a1d adrenergic receptors in the stromal prostatic smooth muscle and bladder neck. Blockade of these adrenoceptors can cause smooth muscles in the bladder neck and prostate to relax, resulting in an improvement in urine flow rate and a reduction in symptoms of BPH. Dutasteride is a competitive and specific inhibitor of both type 1 and type 2, 5 alpha-reductase isoenzymes, with which it forms a stable enzyme complex. Dutasteride inhibits the conversion of testosterone to dihydrotestosterone (DHT). DHT is the androgen primarily responsible for the initial development and subsequent enlargement. Of the prostate gland. Testosterone is converted to DHT by the enzyme 5 alpha-reductase, which exists as 2 isoforms, type 1 and type 2. The type 2 isoenzyme is primarily active in the reproductive tissues, while the type 1 isoenzyme is also responsible for testosterone conversion in the skin and liver.

Common : Dizziness, Impotence, Altered (decreased) libido, Ejaculation disorders and Breast disorders.Uncommon : Cardiac failure.