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Fever & Cough
Paracetamol works to stop the pain messages from getting through to the brain. It also acts in the brain to reduce fever . Chlorpheniramine maleate : This medication works by blocking a certain natural substance (histamine) that your body makes during an allergic reaction. By blocking another natural substance made by your body (acetylcholine), it helps dry up some body fluids to relieve symptoms such as watery eyes and runny nose. Pseudoephedrine is a sympathomimetic with a mixed mechanism of action, direct and indirect. It indirectly stimulates alpha-adrenergic receptors, causing the release of endogenous norepinephrine from the granularity of neurons, while it directly stimulates beta-adrenergic receptors.
Paracetamol : Thrombocytopaenia, Anaphylaxis cutaneous hypersensitivity reactions including amoung others skin rashes, angiodema, stevens johnson syndrome, toxic epidermal necrosis, bronchospasm in patients sensitive to aspirin and other NSAIDs, hepatic dysfuction.Psuedoephedrine: Nervousness, Headache, Dizziness, Insomnia, Increased blood pressure, Vomiting, nausea, Mydriasis, acute angle closure glaucoma, most likely to occur in those with closed angle glaucoma Tachycardia, Palpitations Allergic reactions (e.g. rash, urticaria, allergic dermatitis) Dysuria, urinary retention. This is most likely to occur in those with bladder outlet obstruction such as prostatic hypertrophy.Chlorphenamine : Allergic reactions, angioedema, anaphylactic reactions Anorexia, Confusion*, excitation*, irritability*, nightmares*, Disturbance in attention, abnormal coordination, dizziness, headache Sedation, somnolence Blurred vision, Hypotension, Thickening of bronchial, Secretions, Nausea, dry mouth, Vomiting, abdominal pain, diarrhoea, dyspepsia, Exfoliative dermatitis, rash, urticaria, photosensitivity, Muscle twitching, muscle Weakness, Urinary retention, Fatigue, Chest tightness.