Used For

Tuberculosis

Dosage

Rifampicin , Isoniazid , Pyrazinamide , Ethambutol

Side Effects

Adverse Reactions Relating to Ethambutol – Blood and Lymphatic System Disorders : Leukopenia, thrombocytopenia, neutropenia. Immune System Disorders : Hypersensitivity syndrome consisting of cutaneous reaction (such as rash or exfoliative dermatitis) , eosinophilia, and one or more of the following: hepatitis, pneumonitis, nephritis, myocarditis, and pericarditis. Fever and lymphadenopathy may be present. Metabolism and Nutrition Disorders : Anorexia, elevations of serum uric acid concentration. Nervous System Disorders : Dizziness, hypoesthesia, paresthesia. Gastrointestinal Disorders : Epigastric distress, constipation, nausea, vomiting, abdominal pain, anorexia, metallic taste, dry mouth. Skin and Subcutaneous Tissue Disorders : Pruritus, rash, Stevens-Johnson Syndrome, toxic epidermal necrolysis. Musculoskeletal, Connective Tissue and Bone Disorders : Joint pains, acute gout. Respiratory Disorders, Thoracic and Mediastinal Disorders : Pulmonary infiltrates with or without eosinophilia. Adverse Reactions Relating to Rifampicin: Blood and Lymphatic System Disorders : Thrombocytopenia, leukopenia, hemolytic anemia, anemia, eosinophilia. Thrombocytopenia has occurred when ethambutol and rifampicin were administered concomitantly according to an intermittent dose schedule twice weekly and in high doses. Immune System Disorders : Hypersensitivity reactions Metabolism and Nutrition Disorders : Elevations in serum uric acid. Nervous System Disorders : Headache, drowsiness, fatigue, ataxia, dizziness, inability to concentrate, mental confusion, muscular weakness, generalized numbness, pain in the extremities. Adverse Reactions Relating to Isoniazid: Blood and Lymphatic System Disorders : Agranulocytosis, eosinophilia, anemia, thrombocytopenia, methemoglobinemia, vasculitis, lymphadenopathy. Immune System Disorders : Allergic reactions, lupus-like syndrome, rheumatoid syndrome. Hypersensitivity may result in fever, various skin eruptions, hepatitis, rash (including morbilliform, maculopapular, purpuric, and urticarial), vasculitis, and lymphedema. Ear and Labyrinth Disorders : Tinnitus. Metabolism and Nutrition Disorders : Pellagra, hyperglycemia, metabolic acidosis, gynecomastia. Gastrointestinal Disorders : Epigastric distress, nausea, vomiting, constipation. Adverse Reactions Relating to Pyrazinamide : Blood and Lymphatic System Disorders : Thrombocytopenia, sideroblastic anemia with erythroid hyperplasia, vacuolation of erythrocytes, abnormalities in blood clotting mechanisms, porphyria. Immune System Disorders : Hypersensitivity reactions including rash, urticaria, pruritus. Metabolism and Nutrition Disorders : Anorexia, hyperuricemia. Increased difficulty has been reported in controlling diabetes mellitus when diabetics are given pyrazinamide. Gastrointestinal Disorders : Nausea, vomiting. Skin and Subcutaneous Tissue Disorders : Acne, photosensitivity, skin rashes.